منابع مشابه
Arginine and Cancer
I reviewed the pubmed database using the search terms “L-arginine” and “Cancer” and retrieved over 1,000 articles. Many actually referred to specific nitric oxide studies in lab animals and in vitro cancer cell lines, and overall were too difficult to summarize. Such statements as “NO causes metastasis” would be contradicted in the next article by the statement “NO prevents metastasis and cause...
متن کاملProtein arginine methylation/demethylation and cancer
Protein arginine methylation is a common post-translational modification involved in numerous cellular processes including transcription, DNA repair, mRNA splicing and signal transduction. Currently, there are nine known members of the protein arginine methyltransferase (PRMT) family, but only one arginine demethylase has been identified, namely the Jumonji domain-containing 6 (JMJD6). Although...
متن کاملArginine deprivation and autophagic cell death in cancer.
Our increasing awareness over the last decade, that reprogramming of cellular energetics is a key hallmark of tumorigenesis, has reinvigorated the search for novel tractable metabolic targets in cancer cells (1). From innovative diagnostics based on the tracer 18F-deoxyglucose in positron emission tomography (FDG-PET) to the development of next-generation antimetabolites built on L-asparaginase...
متن کاملMacrophage arginine metabolism and the inhibition or stimulation of cancer.
The potential of the immune system to inhibit or stimulate tumor growth is a vivid example of the "two-edged sword" nature of immune responses. Our results provide evidence that this dual capacity can be attributed, in part, to the dual pathways of arginine metabolism exhibited by intratumor macrophages. Specifically, i.p. tumor rejection in P815-preimmunized mice is accompanied by an upshift i...
متن کاملArginine Metabolism in Bacterial Pathogenesis and Cancer Therapy
Antibacterial resistance to infectious diseases is a significant global concern for health care organizations; along with aging populations and increasing cancer rates, it represents a great burden for government healthcare systems. Therefore, the development of therapies against bacterial infection and cancer is an important strategy for healthcare research. Pathogenic bacteria and cancer have...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2004
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/134.10.2837s